15-Crown-5 (CAS 33100-27-5) is a macrocyclic polyether and sodium-selective ionophore, provided at 98% purity. It features a cavity diameter of 1.7-2.2 Å, complementary to the Na+ ionic radius of 2.04 Å, and binds Na+ with log Ka = 3.24 in methanol. S.Nihar Exports, an ISO 9001:2015 certified fine and specialty chemical supplier, offers this compound with a Certificate of Analysis.
Chemical Profile and Selectivity
15-Crown-5 (CAS 33100-27-5) is characterized as a macrocyclic polyether and sodium-selective ionophore. It possesses a cavity diameter ranging from 1.7 to 2.2 Å, which is structurally complementary to the Na+ ionic radius of 2.04 Å. This compound exhibits selective binding for Na+ with a log Ka of 3.24 in methanol, demonstrating preference over K+ (log Ka = 0.74).
Pharmaceutical and Clinical Applications
In clinical chemistry, 15-Crown-5 is utilized in sodium-selective ISE membranes for the determination of serum sodium concentrations. Its applications are also emerging in wearable sodium sensors designed for sweat electrolyte monitoring, which is relevant in sports science and for assessing clinical dehydration.
Catalysis and Advanced Research
15-Crown-5 functions as a phase-transfer catalyst for sodium salts in organic synthesis. Within research, it is applied in supramolecular chemistry for the synthesis of rotaxanes and catenanes, and in the design of molecular machines. Additionally, it finds use in solid electrolyte research pertinent to sodium-ion batteries.
S.Nihar Exports: Your Supplier for 15-Crown-5
S.Nihar Exports, an ISO 9001:2015 certified fine and specialty chemical supplier, provides 15-Crown-5 (CAS 33100-27-5) at 98% purity. Headquartered in Mumbai, India, at 512 Maker Bhavan 3, New Marine Lines, Mumbai 400020, the company was founded in 1995. S.Nihar Exports is part of N. Himatlal & Co The company A Certificate of Analysis (COA) is provided with every shipment of 15-Crown-5. HPLC-grade, ACS reagent, and indicator-grade variants are available on request.