S.Nihar Exports supplies 2-Bromo-4'-Chloroacetophenone (CAS 536-38-9) with 98% purity. This bifunctional alpha-haloketone serves as a pharmaceutical building block, crucial for synthesizing thiazole, imidazole, and oxazole-containing APIs. Each shipment includes a Certificate of Analysis (COA).
Chemical Profile and Reactivity
2-Bromo-4'-Chloroacetophenone (CAS 536-38-9) is a bifunctional alpha-haloketone, supplied at 98% purity. It features a reactive alpha-bromine group, which functions as an alkylating agent, and a para-chloro substituent suitable for further cross-coupling reactions. This compound is also known by the variant name 4-chlorophenacyl bromide, sharing the same CAS identifier.
Applications in Pharmaceutical Synthesis
This compound is a key building block for the synthesis of various active pharmaceutical ingredients (APIs) containing thiazole, imidazole, and oxazole rings. It is specifically utilized in antifungal drug development, reacting with thiourea to produce 2-amino-4-(4-chlorophenyl)thiazole scaffolds. Its reactivity enables its use as an alkylating agent for both nitrogen and sulfur nucleophiles in drug synthesis, and as a heterocyclic building block for medicinal chemistry libraries.
Sourcing and Quality Assurance
S.Nihar Exports, an ISO 9001:2015 certified fine and specialty chemical supplier, offers 2-Bromo-4'-Chloroacetophenone. Headquartered at 512 Maker Bhavan 3, New Marine Lines, Mumbai 400020, India, S.Nihar Exports was founded in 1995 and is part of N. Himatlal & Co. The company A Certificate of Analysis (COA) is provided with every shipment, and HPLC-grade, ACS reagent, and indicator-grade variants are available upon request.