4-Bromothiophenol (CAS 106-53-6) is an organosulfur building block and cross-coupling reagent, verified with 98% purity. With molecular formula C6H5BrS and molecular weight 189.08 g/mol, it is supplied by S.Nihar Exports. S.Nihar Exports, an ISO 9001:2015 certified fine and specialty chemical supplier, serves global pharmaceutical manufacturers and R&D labs.
Chemical Structure and Reactivity
4-Bromothiophenol (CAS 106-53-6), exhibiting 98% purity, is a bifunctional reagent with molecular formula C6H5BrS and molecular weight of 189.08 g/mol. Its thiol group enables nucleophilic chemistry, reacting selectively with maleimides, acrylates, and participating in thiol-ene click chemistry. The aryl bromide functionality allows for palladium-catalyzed cross-coupling reactions, including Suzuki, Buchwald-Hartwig, and carbonylative couplings.
Applications in Synthesis and Materials Science
This organosulfur building block is utilized in the synthesis of diaryl sulfides via thiol S-arylation reactions. It serves as a key intermediate for sulfinates and sulfonamide pharmaceuticals. Beyond pharmaceutical applications, 4-Bromothiophenol is used in the preparation of self-assembled monolayers (SAM) on gold surfaces for biosensor fabrication and electrochemistry, and in polymer modification through thiol-ene click chemistry. It acts as a pharmaceutical intermediate for sulfonamide and sulfide APIs.
Sourcing from S.Nihar Exports
S.Nihar Exports, an ISO 9001:2015 certified fine and specialty chemical supplier, offers 4-Bromothiophenol (CAS 106-53-6) within its catalog of. Founded in 1995 and part of N. Himatlal & Co, the company is headquartered in Mumbai, India (512 Maker Bhavan 3, New Marine Lines, Mumbai 400020). S.Nihar Exports supplies pharmaceutical manufacturers, R&D labs, and life sciences companies globally. A Certificate of Analysis (COA) is provided with every shipment, and HPLC-grade, ACS reagent, and indicator-grade variants are available upon request.