Homophthalic Acid (2-(2-carboxyphenyl)acetic acid, CAS 89-51-0) is a white crystalline solid with 98% purity, molecular formula C9H8O4, and molecular weight 180.16 g/mol. S.Nihar Exports, an ISO 9001:2015 certified fine and specialty chemical supplier, provides this pharmaceutical intermediate globally.
Chemical Profile and Properties
Homophthalic Acid (CAS 89-51-0) is identified as a white crystalline solid with a purity of 98%. Its molecular formula is C9H8O4, and its molecular weight is 180.16 g/mol. This compound is known chemically as 2-(2-carboxyphenyl)acetic acid.
Synthetic Utility
Homophthalic acid cyclizes to homophthalic anhydride upon heating, serving as a key precursor for isochromanone synthesis. It is also utilized in the synthesis of 3-substituted isocoumarins and isoindolinones through specific ring-closure reactions.
Applications and End-Uses
Homophthalic acid is a critical intermediate in medicinal chemistry, specifically for the synthesis of isochromanone and isocoumarin scaffolds. The isochromanone scaffold is present in natural products like mellein and in pharmaceutical compounds with reported anti-inflammatory and antifungal activity. It facilitates the synthesis of isoindolinone scaffolds for CNS drug candidates. Additionally, homophthalic acid finds application as a dye intermediate and in UV-absorber synthesis.
Sourcing Homophthalic Acid from S.Nihar Exports
S.Nihar Exports supplies Homophthalic Acid (CAS 89-51-0) to pharmaceutical manufacturers, R&D labs, and life sciences companies worldwide. As an ISO 9001:2015 certified fine and specialty chemical supplier, S.Nihar Exports operates from its headquarters in Mumbai, India (512 Maker Bhavan 3, New Marine Lines, Mumbai 400020). The company was founded in 1995 and is part of N. Himatlal & Co. S.Nihar Exports offers and provides a Certificate of Analysis (COA) with every shipment. HPLC-grade, ACS reagent, and indicator-grade variants of Homophthalic Acid are available upon request.